Yes, CullAi works well with Adobe Lightroom and other Editing Apps like Capture One. You can directly import photos from Lightroom into CullAi and after culling you can update metadata which will get synced to Lightroom. You can check out our Getting Started Guide for Lightroom.
It also reads and updates Rating and Color Label Metadata which can then be synced to and from any editing app that follows XML, EXIF, IPTC standards. Please check our user guide on Metadata to learn more.